Michael Carrick and Dimitar Berbatov face a race against time to be fit for Saturday's trip to Tottenham, but Cristiano Ronaldo is expected to be involved.
Ronaldo missed Wednesday's 2-2 draw with Aalborg because of the hip injury sustained during last weekend's victory over Sunderland.
Carrick and Berbatov also sat out the Reds' final Champions League group game at Old Trafford and doubts remain over their fitness ahead of Saturday's tea-time visit to their former club.
"Berbatov and Carrick are the main worries," Sir Alex Ferguson told MUTV.
"I'm sure Ronaldo will be okay. His hip is still a bit tender, but hopefully he'll be back."
ManUtd.com will bring you the latest injury news from the manager's press conference on Friday morning.
點解2個熱刺舊部都會