Chelsea pair Frank Lampard and Ryan Bertrand have pulled out of the England squad for Friday's World Cup qualifier against San Marino at Wembley.
Midfielder Lampard, 34, has a knee injury and full-back Bertrand, 23, a sore throat.
The Football Association confirmed they will return to their club for treatment over the weekend.
They will rejoin the England squad on Sunday for assessment ahead of the game in Poland on Tuesday.
Bertand and Liverpool's Jonjo Shelvey were called into the squad after Kieran Gibbs pulled out.
Left-back Gibbs, 23, withdrew after sustaining a thigh strain in Arsenal's victory over West Ham.
Bertrand, also 23, made his senior England debut against Italy in August and was a direct replacement for Gibbs, while for midfielder Shelvey, 20, it was his first England call-up.
Shelvey was initially called up for the European Under-21 Championship play-off with Serbia by Stuart Pearce.
However, the Londoner is suspended for the first leg of that game at Norwich, prompting Hodgson to bring him into the senior fold.
His presence at St George's Park is purely to further his experience.
He could return to the Under-21s for the second leg of the Serbia game next Tuesday, although a decision will not be taken until the weekend.
England squad
Goalkeepers: Fraser Forster (Celtic), Joe Hart (Manchester City), John Ruddy (Norwich)
Defenders: Leighton Baines (Everton), Gary Cahill (Chelsea), Ashley Cole (Chelsea), Phil Jagielka (Everton), Glen Johnson (Liverpool), Joleon Lescott (Manchester City), Ryan Shawcross (Stoke), Kyle Walker (Tottenham)
Midfielders: Michael Carrick (Manchester United), Tom Cleverley (Manchester United), Steven Gerrard (Liverpool), Adam Johnson (Sunderland), Aaron Lennon (Tottenham), James Milner (Manchester City), Alex Oxlade-Chamberlain (Arsenal), Jonjo Shelvey (Liverpool), Theo Walcott (Arsenal)
Forwards: Andy Carroll (West Ham), Jermain Defoe (Tottenham), Wayne Rooney (Manchester United), Danny Welbeck (Manchester United)
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